منابع مشابه
Pathology of Neurodegenerative Diseases
As the average life expectancy has been extended by the current state-of-art medical technologies, the elderly population is increasing rapidly. The world is now facing the ‘ageing era’, which comes with social issues like neurodegenerative diseases. Neurodegenerative diseases are progressive neurological disorders highly linked to brain injuries from which there is no recovery. Selective neuro...
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The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway sustaining the delivery of proteins from their site of synthesis in the endoplasmic reticulum to their final destination, the extracellular medium, the plasma membrane, and the endo-lysosomal system. It ensures post-translational protein modifications such as glycosylation and proteolytic cleavage and pro...
متن کاملThe cellular basis of dendrite pathology in neurodegenerative diseases
One of the characteristics of the neurons that distinguishes them from other cells is their complex and polarized structure consisting of dendrites, cell body, and axon. The complexity and diversity of dendrites are particularly well recognized, and accumulating evidences suggest that the alterations in the dendrite structure are associated with many neurodegenerative diseases. Given the import...
متن کاملHemichannels in neurodegenerative diseases: is there a link to pathology?
Although originally considered a structural component of gap junctions, connexin hemichannels (HCs) are now recognized as functional entities capable of influencing metabolic gradients within the CNS, allowing direct communication between the intra- and extracellular milieus. Besides connexins, HCs can also be formed by pannexins, which are not capable of gap junction assembly. Both positive an...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2017
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a028035